2. Academic Validation
  3. Cytotoxic α-pyrone derivatives from Cryptocarya yunnanensis

Cytotoxic α-pyrone derivatives from Cryptocarya yunnanensis

  • Nat Prod Res. 2022 Feb;36(4):918-924. doi: 10.1080/14786419.2020.1849205.
Qian He 1,  Yue Fan 1,  Yu Liu 1,  Yun-Xia You 1,  Li Rao 1,  Yu Su 1,  You-Kai Xu 2,  Bin Lin 3,  Chuan-Rui Zhang 1 4
Affiliations

Affiliations

  • 1 Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, and Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University , Chongqing , P.R. China.
  • 2 Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences , Menglun , P.R. China.
  • 3 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang , P.R. China.
  • 4 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , P.R. China.
PMID: 33207963 DOI: 10.1080/14786419.2020.1849205
Abstract

Five new α-pyrone derivatives, cryptoyunnanes A - E (1 - 5), together with four known analogues, were isolated from the leaves and twigs of Cryptocarya yunnanensis. Their structures including absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism (ECD) analyses. Compounds 4 and 6 showed significant cytotoxicity against A549, HCT-116, MDA-MB-231, PC-3 and HeLa with IC50 values from 2.25 to 8.97 µM. Compounds 1, 2 and 7 also displayed good cytotoxicity against HCT-116, MDA-MB-231 and PC-3 with IC50 values from 1.26 to 8.32 µM. This is the first time to report the isolation and bioactivity evaluation of chemical constituents from C. yunnanensis.

Keywords

Cryptocarya yunnanensis; cytotoxicity; spectroscopic data; α-pyrones.

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