2. Academic Validation
  3. Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46

Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46

  • Biosci Biotechnol Biochem. 2021 May 25;85(6):1526-1529. doi: 10.1093/bbb/zbab061.
Ichie Ojiro 1,  Hiromi Nishio 1,  Toyomi Yamazaki-Ito 1 2,  Shogo Nakano 1 2,  Sohei Ito 1 2,  Yoshikazu Toyohara 3,  Tadahiro Hiramoto 3,  Yuko Terada 1 2,  Keisuke Ito 1 2
Affiliations

Affiliations

  • 1 Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
  • 2 School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
  • 3 Corporate Research and Development Division, Takasago International Corporation, Hiratsuka, Kanagawa, Japan.
PMID: 33844825 DOI: 10.1093/bbb/zbab061
Abstract

Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multifunctional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods.

Keywords

bitter taste receptor; bitterness masking; dipeptide.

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