2. Academic Validation
  3. HSP47 contributes to angiogenesis by induction of CCL2 in bladder cancer

HSP47 contributes to angiogenesis by induction of CCL2 in bladder cancer

  • Cell Signal. 2021 Sep;85:110044. doi: 10.1016/j.cellsig.2021.110044.
Wenlong Ma 1,  Tong Ou 2,  Xiangrui Cui 3,  Kai Wu 1,  Hongming Li 4,  Yuqing Li 1,  Guoyu Peng 1,  Wuchao Xia 1,  Song Wu 5
Affiliations

Affiliations

  • 1 Institute of Urology, The Third Affiliated Hospital of Shenzhen University (Luohu Hospital Group), Shenzhen 518000, China; Shenzhen Following Precision Medical Research Institute, Luohu Hospital Group, Shenzhen 518000, China.
  • 2 Institute of Urology, The Third Affiliated Hospital of Shenzhen University (Luohu Hospital Group), Shenzhen 518000, China; Shenzhen Following Precision Medical Research Institute, Luohu Hospital Group, Shenzhen 518000, China; Medical Laboratory, The Third Affiliated Hospital of Shenzhen University (Luohu Hospital Group), Shenzhen 518001, China.
  • 3 Medical Laboratory, The Third Affiliated Hospital of Shenzhen University (Luohu Hospital Group), Shenzhen 518001, China.
  • 4 Mudanjiang Medical College, Mudanjiang 157011, China.
  • 5 Institute of Urology, The Third Affiliated Hospital of Shenzhen University (Luohu Hospital Group), Shenzhen 518000, China; Shenzhen Following Precision Medical Research Institute, Luohu Hospital Group, Shenzhen 518000, China; Teaching Center of Shenzhen Luohu Hospital, Shantou University Medical College, Shenzhen 518000, China. Electronic address: [email protected].
PMID: 34000383 DOI: 10.1016/j.cellsig.2021.110044
Abstract

Heat Shock Protein 47 (HSP47) is a collagen-specific molecular chaperone and is involved in tumor progression by promoting angiogenesis. However, the regulatory network of HSP47 in angiogenesis remains elusive. In this study, we report a novel mechanism of HSP47-induced angiogenesis in bladder Cancer (BC). We find that HSP47 is abnormally overexpressed in BC and is correlated with poor prognosis. HSP47 down-regulation suppresses angiogenesis in BC cells. Mechanistically, activation of the ERK pathway and induction of C-C Motif Chemokine Ligand 2 (CCL2) are responsible for HSP47-induced angiogenesis. The correlation between HSP47 with CCL2 and angiogenesis is further confirmed in BC clinical samples. Taken together, our findings suggest that HSP47 contributes to BC angiogenesis by induction of CCL2 and provide a potential anti-angiogenesis target for BC therapy.

Keywords

Angiogenesis; Bladder cancer; CCL2; ERK pathway; HSP47.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-50846
    99.27%, ERK1/2 Inhibitor
    ERK