Design, synthesis and biological evaluation of novel molecules as potent PARP-1 inhibitors

Bioorg Med Chem Lett. 2021 Sep 1:47:128169. doi: 10.1016/j.bmcl.2021.128169.

Hui Shen ¹, Yiran Ge ², Junwei Wang ¹, Hui Li ¹, Yungen Xu ³, Qihua Zhu ⁴

Affiliations

1 Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 211198, China.
2 Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.
3 Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 211198, China; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China. Electronic address: [email protected].
4 Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 211198, China; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China. Electronic address: [email protected].

PMID: 34091044 DOI: 10.1016/j.bmcl.2021.128169

Abstract

Two series of novel compounds with inhibition activity against PARP-1 were designed and synthesized. All target compounds were evaluated for their PARP-1 inhibition activity, and compounds with high PARP-1 inhibition activity were selected to assess for cellular assays in vitro. Among them, compound II-4 displayed impressive results in both PARP-1 enzyme inhibition with IC₅₀ value of 0.51 nM and anti-proliferation activity against HCT116 and HCC1937 cell lines with IC₅₀ values of 6.62 nM and 12.65 nM, respectively. Also, II-4 exhibited good metabolic stability in vitro with t_1/2 of 173.25 min and CL_int of 0.04 mL/min/mg. Prediction of molecular properties and protein docking were applied to structure design. Our study provides potential lead compounds and design directions for the development of PARP-1 inhibitors.

Keywords

Antitumor drug; DNA repair; Drug design; PARP-1 inhibitors.

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