2. Academic Validation
  3. New cytotoxic aristolactams from Pararistolochia flos-avis

New cytotoxic aristolactams from Pararistolochia flos-avis

  • J Nat Prod. 1987 Sep-Oct;50(5):843-6. doi: 10.1021/np50053a011.
N J Sun 1,  M Antoun,  C J Chang,  J M Cassady
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
PMID: 3437282 DOI: 10.1021/np50053a011
Abstract

Two new aristolactams, aristolactam-FI [1] and -FII [2], were isolated from active extracts of Pararistolochia flos-avis. Their structures were elucidated on the basis of nmr, ms, uv, and ir spectral data. Aristolactam-I [3] and -AII [4] were also isolated from this plant. Aristolactam-AII showed cytotoxicity against PS and KB cells in culture.

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