Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently

Affiliations

• 1 MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, China.
• 2 MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.
• 3 Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
• 4 Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing, China.
• 5 MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, China. [email protected].
• # Contributed equally.