2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs Molecular Glues Btk
  4. GBD-9

GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth.

For research use only. We do not sell to patients.

GBD-9 Chemical Structure

GBD-9 Chemical Structure

CAS No. : 2864408-92-2

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5 mg USD 470 In-stock
10 mg USD 752 In-stock
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Based on 1 publication(s) in Google Scholar

GBD-9 Related Antibodies

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Description

GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

797.90

Formula

C44H47N9O6
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1N(C2CCC(NC2=O)=O)C(C(C1=C3)=CC=C3NCCCCCCCCC(N4CCC[C@@H](N5N=C(C6=CC=C(OC7=CC=CC=C7)C=C6)C8=C5N=CN=C8N)C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (125.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2533 mL 6.2664 mL 12.5329 mL
5 mM 0.2507 mL 1.2533 mL 2.5066 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2533 mL 6.2664 mL 12.5329 mL 31.3322 mL
5 mM 0.2507 mL 1.2533 mL 2.5066 mL 6.2664 mL
10 mM 0.1253 mL 0.6266 mL 1.2533 mL 3.1332 mL
15 mM 0.0836 mL 0.4178 mL 0.8355 mL 2.0888 mL
20 mM 0.0627 mL 0.3133 mL 0.6266 mL 1.5666 mL
25 mM 0.0501 mL 0.2507 mL 0.5013 mL 1.2533 mL
30 mM 0.0418 mL 0.2089 mL 0.4178 mL 1.0444 mL
40 mM 0.0313 mL 0.1567 mL 0.3133 mL 0.7833 mL
50 mM 0.0251 mL 0.1253 mL 0.2507 mL 0.6266 mL
60 mM 0.0209 mL 0.1044 mL 0.2089 mL 0.5222 mL
80 mM 0.0157 mL 0.0783 mL 0.1567 mL 0.3917 mL
100 mM 0.0125 mL 0.0627 mL 0.1253 mL 0.3133 mL
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GBD-9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GBD-92864408-92-2GBD9GBD 9PROTACsMolecular GluesBtkBruton tyrosine kinaseBTKGSPT1CRBNPROTACmolecular glueInhibitorinhibitorinhibit

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