Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently

  • Cell Res. 2021 Dec;31(12):1315-1318. doi: 10.1038/s41422-021-00533-6.
Zimo Yang  #  1 ,  Yonghui Sun  #  1 ,  Zhihao Ni  1 ,  Celi Yang  2  3  4 ,  Yan Tong  1 ,  Yujie Liu  1 ,  Haitao Li  2  3  4 ,  Yu Rao  5
Affiliations
  • 1. MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, China.
  • 2. MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, China.
  • 3. Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
  • 4. Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing, China.
  • 5. MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, China. [email protected].
  • # Contributed equally.
PMID: 34417569 DOI: 10.1038/s41422-021-00533-6
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