2. Academic Validation
  3. TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease

TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease

  • Front Immunol. 2021 Sep 6:12:738473. doi: 10.3389/fimmu.2021.738473.
Esther L Jones 1,  Stephen M Laidlaw 1,  Lynn B Dustin 1
Affiliations

Affiliation

  • 1 Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
PMID: 34552597 DOI: 10.3389/fimmu.2021.738473
Abstract

TRIM21 (Ro52/SSA1) is an E3 ubiquitin Ligase with key roles in immune host defence, signal transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's syndrome, systemic lupus erythematosus, and Other rheumatic autoimmune diseases. Here, we summarise the structure and function of this enzyme, its roles in innate immunity, adaptive immunity and cellular homeostasis, the pathogenesis of autoimmunity against TRIM21, and the potential impacts of autoantibodies to this intracellular protein.

Keywords

E3 ubiquitin ligase; Fc receptor; Sjogren’s syndrome; autoimmune disease; innate immunity; intracellular antibodies; systemic lupus erythematosus.

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