1. Academic Validation
  2. Antibody-Antineoplastic Conjugates in Gynecological Malignancies: Current Status and Future Perspectives

Antibody-Antineoplastic Conjugates in Gynecological Malignancies: Current Status and Future Perspectives

  • Pharmaceutics. 2021 Oct 15;13(10):1705. doi: 10.3390/pharmaceutics13101705.
Cristina Martín-Sabroso 1 2 Irene Lozza 1 Ana Isabel Torres-Suárez 1 2 Ana Isabel Fraguas-Sánchez 1 2
Affiliations

Affiliations

  • 1 Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.
  • 2 Institute of Industrial Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.
Abstract

In the last decade, antibody-drug conjugates (ADCs), normally formed by a humanized antibody and a small drug via a chemical cleavable or Non-cleavable Linker, have emerged as a potential treatment strategy in Cancer disease. They allow to get a selective delivery of the chemotherapeutic agents at the tumor level, and, consequently, to improve the antitumor efficacy and, especially to decrease chemotherapy-related toxicity. Currently, nine antibody-drug conjugate-based formulations have been already approved and more than 80 are under clinical trials for the treatment of several tumors, especially breast Cancer, lymphomas, and multiple myeloma. To date, no ADCs have been approved for the treatment of gynecological formulations, but many formulations have been developed and have reached the clinical stage, especially for the treatment of ovarian Cancer, an aggressive disease with a low five-year survival rate. This manuscript analyzes the ADCs formulations that are under clinical research in the treatment of gynecological carcinomas, specifically ovarian, endometrial, and cervical tumors.

Keywords

auristatins; cervical cancer; endometrial cancer; maytansinoids; mirvetuximab soravtansine; ovarian cancer; sacituzumab govitecan; targeted-chemotherapy; trastuzumab deruxtecan.

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