Praluzatamab
Based on 1 Customer Validation
Praluzatamab is a monoclonal antibody targeting the activated leukocyte cell adhesion molecule (ALCAM/CD116). Praluzatamab can be used to synthesize Praluzatamab ravtansine (antibody-drug conjugates). Praluzatamab can be used for research of cancers.
For research use only. We do not sell to patients.
- Purity : 99.14%
- CAS No.: 2145109-70-0
- Molecular Weight:146.9 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
ALCAM/CD166
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:H292 tumor-bearing mice (female, 8 weeks, 18-25 g, injected subcutaneously in both flanks with 5 × 106 H292 human lung cancer cells)[2]
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Dosage:10, 110, 510 µg or 5 mg/kg
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Administration:Intravenous injection (i.v.)
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Result:At 72 hours after injection, the tumor uptake was the highest in the 10 µg and 110 µg groups.
Reduced the size of the tumor.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized ALCAM/CD166 Protein, Human (HEK293, Fc, HY-P7471) can bind Praluzatamab. The EC50 for this effect is 13.78 ng/mL. -
Flow cytometric analysis of 106 Jurkat cells with Praluzatamab (HY-P99788, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor® 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control
Chemical Information
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CAS No. 2145109-70-0
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Appearance Liquid
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Molecular Weight 146.9 kDa
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Color Colorless to light yellow
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SMILES
[Praluzatamab]
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Synonyms
CX-191; CX-2009 Antibody
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Martín-Sabroso C, et al. Antibody-Antineoplastic Conjugates in Gynecological Malignancies: Current Status and Future Perspectives. Pharmaceutics. 2021 Oct 15;13(10):1705. [Content Brief]
[2]. Chomet M, et al. The tumor targeting performance of anti-CD166 Probody drug conjugate CX-2009 and its parental derivatives as monitored by 89Zr-immuno-PET in xenograft bearing mice. Theranostics. 2020 Apr 27;10(13):5815-5828. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)