ALCAM - activated leukocyte cell adhesion molecule Gene

Also Known as MEMD; CD166

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 214

About ALCAM

Cytogenetic location: 3q13.11 Genomic coordinates (GRCh38): 3:105,366,909-105,576,900 (from NCBI)

This gene has 9 transcripts (splice variants), 258 orthologues and 3 paralogues. Broad expression in lung (RPKM 33.7), brain (RPKM 28.3) and 24 other tissues.

Summary

This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]

ALCAM Products (4)

mRNA	Protein	Name
NM_001243280.2	NP_001230209.1	CD166 antigen isoform 2 precursor
NM_001243281.2	NP_001230210.1	CD166 antigen isoform 3 precursor
NM_001243283.2	NP_001230212.1	CD166 antigen isoform 4 precursor
NM_001627.4	NP_001618.2	CD166 antigen isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	26146185	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24945728	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: Inferred from mutant phenotype	16352806	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of T cell receptor complex	IDA IDA: Inferred from direct assay	15294938	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	15294938	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15294938	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALCAM Protein Structure

V-set

C2-set_2

Ig_2

Ig_3

0
100
200
300
400
500
583 a.a.

Protein Preferred Names	Protein Names
CD166 antigen

ALCAM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ALCAM	Q13740	LGALS1	Homo sapiens	P09382	Competition Binding	24945728
Intra	ALCAM	Q13740	LGALS1	Homo sapiens	P09382	ELISA	24945728
Intra	ALCAM	Q13740	LGALS1	Homo sapiens	P09382	Anti Tag CoIP	33961781
Intra	ALCAM	Q13740	LGALS3	Homo sapiens	P17931	Pull Down	24945728
Intra	ALCAM	Q13740	LGALS3	Homo sapiens	P17931	ELISA	24945728
Intra	ALCAM	Q13740	ALCAM	Homo sapiens	Q13740	GMS	26146185
Intra	ALCAM	Q13740	CD6	Homo sapiens	P30203	Competition Binding	24945728
Intra	ALCAM	Q13740	CD6	Homo sapiens	P30203	ELISA	24945728
Intra	ALCAM	Q13740	ALCAM	Homo sapiens	Q13740	Light Scattering	26146185
Intra	ALCAM	Q13740	ALCAM	Homo sapiens	Q13740	SLCA	26146185
Intra	ALCAM	Q13740	ABCC1	Homo sapiens	P33527	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALCAM Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7471	ALCAM/CD166 Protein, Human (HEK293, Fc)	Q13740 (W28-A526)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78056	ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His)	Q13740 (W28-A526)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78057	ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His-Avi)	Q13740 (W28-A526)	≥ 95%, as determined by Bis-Tris PAGE.

ALCAM Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81138	CD166 Antibody (YA3492)	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
HY-P81138A	CD166 Antibody (YA3492)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
HY-P84554	CD166 Antibody (YA4251)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84554A	CD166 Antibody (YA4251)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84555	CD166 Antibody (YA4252)	WB, IHC-P, FC, ELISA	Human
HY-P84555A	CD166 Antibody (YA4252)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P85083	CD166 Antibody (YA4775)	WB, ELISA	Human
HY-P85084	CD166 Antibody (YA4776)	IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Stork Bite	Salmon Patch Nevus Unna'S Nevus
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00557	ALCAM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17128	Alcam Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23573	Alcam Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99788	Praluzatamab	Inhibitor	99.14%	Unkown
HY-P991532	AT002	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ALCAM	MGD	MGI:1313266
Canis familiaris	ALCAM	VGNC	VGNC:37779
Rattus norvegicus	ALCAM	RGD	RGD:619972
Bos taurus	ALCAM	VGNC	VGNC:25805
Macaca mulatta	ALCAM	VGNC	VGNC:69783
Felis catus	ALCAM	VGNC	VGNC:59735
Others	ALCAM	NCBI