CD166 Antibody (YA4776)
(Synonyms: ALCAM; MEMD; CD166 antigen; Activated leukocyte cell adhesion molecule; CD antigen CD166)CD166 Antibody (YA4776) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD166.
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Host:
Mouse
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Application:
IHC-P, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 | 1:50-200 |
Product Details
CD166 Antibody (YA4776) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD166.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
Purified recombinant fragment of CD166 (aa405-524) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD166 cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation. Required for normal hematopoietic stem cell engraftment in the bone marrow. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation. Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons; Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation[1][2][3][4][5][6][7][8][9].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Cell projection, axon; Cell projection, dendrite; Secreted
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Expression
Tissue_specificity:Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813) . Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771) . Detected on peripheral blood monocytes (PubMed:15048703) . Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806) . Detected at low levels in spleen, placenta, liver (PubMed:9502422) . Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007) . Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415) . Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422)
Induction:Up-regulated by TNF and IFNG (at protein level) -
Isoforms & Post-Translational Modification
Q13740 has 4 isomers: Q13740-1: 65102 Da (predicted); Q13740-2: 63665 Da (predicted); Q13740-3: 15109 Da (predicted); Q13740-4: 33878 Da (predicted).
Glycosylated -
Subunit
Homodimer (PubMed:15048703, PubMed:16352806, PubMed:26146185, PubMed:7760007). Interacts (via extracellular domain) with CD6 (via extracellular domain) (PubMed:15048703, PubMed:16914752, PubMed:24945728, PubMed:26146185, PubMed:7760007, PubMed:8823162).
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SwissProt ID
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Synonyms
ALCAM; MEMD; CD166 antigen; Activated leukocyte cell adhesion molecule; CD antigen CD166
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