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  5. CD166 Antibody (YA4252)

CD166 Antibody (YA4252) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD166.

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容量 価格（税別） 在庫状況 数量
20 μL $167 Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL $252 Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL $408 Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   お問い合わせ  
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* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

CD166 Antibody (YA4252) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD166.
Host

Mouse
Clonality

Monoclonal
分子量
Predicted band size: 65 kDa;
Observed band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Purified recombinant fragment of human CD166 (AA: extra 227-381) expressed in E. Coli.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:2000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:200-1:1000
FC
FC: Flow Cytometry
1:200-1:400
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:10000
純度 affinity purified. Conjugation Non-conjugated
Modification Unmodified Isotype IgG1
Appearance

Liquid
Formulation

Supplied in PBS with 0.05% sodium azide
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:15048703, PubMed:15496415, PubMed:16352806, PubMed:23169771, PubMed:24945728, PubMed:7760007). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation (PubMed:29263213). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity); Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation
Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Cell projection, axon; Cell projection, dendrite; Secreted
Expression：
Tissue_specificity:Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813) . Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771) . Detected on peripheral blood monocytes (PubMed:15048703) . Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806) . Detected at low levels in spleen, placenta, liver (PubMed:9502422) . Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007) . Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415) . Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422)

Induction:Up-regulated by TNF and IFNG (at protein level)
Isoforms & Post-Translational Modification：Q13740 has 4 isomers: Q13740-1: 65102 Da (predicted); Q13740-2: 63665 Da (predicted); Q13740-3: 15109 Da (predicted); Q13740-4: 33878 Da (predicted).
Glycosylated
Subunit：Homodimer (PubMed:15048703, PubMed:16352806, PubMed:26146185, PubMed:7760007). Interacts (via extracellular domain) with CD6 (via extracellular domain) (PubMed:15048703, PubMed:16914752, PubMed:24945728, PubMed:26146185, PubMed:7760007, PubMed:8823162).
Synonyms
MEMD; ALCAM
ドキュメンテーション
User Guide for Antibodies (1077 KB)

CD166 Antibody (YA4252) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
CD166 Antibody (YA4252)
製品番号:
HY-P84555
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