2. Academic Validation
  3. Precursor-Directed Biosynthesis of Talaroenamine Derivatives Using a Yellow River Wetland-Derived Penicillium malacosphaerulum

Precursor-Directed Biosynthesis of Talaroenamine Derivatives Using a Yellow River Wetland-Derived Penicillium malacosphaerulum

  • J Nat Prod. 2021 Nov 26;84(11):2923-2928. doi: 10.1021/acs.jnatprod.1c00696.
Zhenzhen Zhang 1,  Xueqian He 1,  Huadong Li 1,  Zhenzhen Liu 1,  Chao Niu 1,  Lanping Yang 1,  Yangyang Zhai 1,  Baohua Hou 1,  Baobao Zhang 1,  Xiaomin Zhang 2,  Dehai Li 2,  Jingchun Zhou 3,  Zhenhui Wang 1
Affiliations

Affiliations

  • 1 College of Medicine, Henan Polytechnic University, Jiaozuo 454000, People's Repubilc of China.
  • 2 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Repubilc of China.
  • 3 Beijing Bencaoyuan Pharmaceutical Co., Ltd, Beijing 102629, People's Repubilc of China.
PMID: 34762445 DOI: 10.1021/acs.jnatprod.1c00696
Abstract

Precursor-directed biosynthesis was used to introduce selected aniline derivatives into the talaroenamine pathway, which had recently been defined from a Yellow River wetland-derived Penicillim malacosphaerulum HPU-J01. The known talaroenamine B (1) and six previously undescribed talaroenamine derivatives, talaroenamines F-K (2-7), were generated and structurally characterized. The aniline derivatives are introduced via nonenzymatic addition to the reactive intermediate cyclohexanedione. Compound 2 was active against Bacillus cereus with an MIC value of 0.85 μg/mL.

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