2. Academic Validation
  3. Uncovering a Key Role of ETS1 on Vascular Abnormality in Glioblastoma

Uncovering a Key Role of ETS1 on Vascular Abnormality in Glioblastoma

  • Pathol Oncol Res. 2021 Nov 19;27:1609997. doi: 10.3389/pore.2021.1609997.
Jiefu Tang 1,  Yaling Li 2,  Boxuan Liu 3,  Wei Liang 4,  Sanbao Hu 5,  Meilian Shi 6,  Jie Zeng 4,  Mingzhen Li 3,  Minjiang Huang 7
Affiliations

Affiliations

  • 1 Trauma Center, The First Affiliated Hospital of Hunan University of Medicine, Huaihua, China.
  • 2 Department of Obstetrics and Gynaecology, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China.
  • 3 Precision Medicine Center, The Second People's Hospital of Huaihua, Huaihua, China.
  • 4 Department of Orthopaedics, The Second People's Hospital of Huaihua, Huaihua, China.
  • 5 Department of Orthopaedics, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • 6 Department of Infectious Diseases, The Second People's Hospital of Huaihua, Huaihua, China.
  • 7 Hunan University of Medicine, Huaihua, China.
PMID: 34867089 DOI: 10.3389/pore.2021.1609997
Abstract

Glioblastoma (GBM) is the most aggressive type of brain tumor. Microvascular proliferation and abnormal vasculature are the hallmarks of the GBM, aggravating disease progression and increasing patient morbidity. Here, we uncovered a key role of ETS1 on vascular abnormality in glioblastoma. ETS1 was upregulated in endothelial cells from human tumors compared to endothelial cells from paired control brain tissue. Knockdown of Ets1 in mouse brain endothelial cells inhibited cell migration and proliferation, and suppressed expression of genes associated with vascular abnormality in GBM. ETS1 upregulation in tumor ECs was dependent on TGFβ signaling, and targeting TGFβ signaling by inhibitor decreased tumor angiogenesis and vascular abnormality in CT-2A glioma model. Our results identified ETS1 as a key factor regulating tumor angiogenesis, and suggested that TGFβ inhibition may suppress the vascular abnormality driven by ETS1.

Keywords

ETS1; endothelial; glioblastoma; tumor vessel; vascular abnormality.

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