2. Academic Validation
  3. The triterpenoids and sesquiterpenoids from the plant of Agrimonia pilosa

The triterpenoids and sesquiterpenoids from the plant of Agrimonia pilosa

  • Fitoterapia. 2022 Mar;157:105104. doi: 10.1016/j.fitote.2021.105104.
Jia Zhang 1,  Ya-Nan Yang 2,  Zi-Ming Feng 2,  Xiang Yuan 2,  Xu Zhang 2,  Jian-Shuang Jiang 3,  Pei-Cheng Zhang 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
  • 2 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.
  • 3 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. Electronic address: [email protected].
  • 4 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. Electronic address: [email protected].
PMID: 34923054 DOI: 10.1016/j.fitote.2021.105104
Abstract

A phytochemistry of the whole plant of Agrimonia pilosa led to the discovery of two new nortriterpenoids, agrimonorterpenes A and B (1 and 2), together with one known triterpenoid fupenzic acid (3) and seven known sesquiterpenoids (4-10). The new structures were determined as 19α-hydroxy-2-oxo-nor-A (3)-urs-11,12-dien-28-oic acid (1) and 2, 19β-dihydroxy-3-oxo-23-noroleana-1, 4, 12-trien-28-oic acid (2) by the spectroscopic data of UV, IR, HR-ESI-MS, and NMR. Notably, the structure of 1 possessed a rare five-membered A- ring. And this is the first time to discover the sesquiterpenoids (4-10) from A. pilosa. Compound 3 displayed the selective cytotoxicity against HCT116, BGC823, and HepG2 cell lines with the IC50 values of 16.31 μM, 21.94 μM, and 23.40 μM, respectively.

Keywords

Agrimonia pilosa; Cytotoxicity; Nortriterpenoid; Sesquiterpenoid; Structural elucidation.

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