2. Academic Validation
  3. Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities

Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities

  • Eur J Med Chem. 2022 Feb 5:229:114085. doi: 10.1016/j.ejmech.2021.114085.
Xiaoying Jiang 1,  Kaiyu Wu 2,  Renren Bai 3,  Pengfei Zhang 4,  Yi Zhang 5
Affiliations

Affiliations

  • 1 Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China; College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, PR China.
  • 2 College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, PR China.
  • 3 School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China. Electronic address: [email protected].
  • 4 College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, PR China. Electronic address: [email protected].
  • 5 Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China. Electronic address: [email protected].
PMID: 34998058 DOI: 10.1016/j.ejmech.2021.114085
Abstract

Quinoxalinones are a class of heterocyclic compounds which attract extensive attention owing to their potential in the field of organic synthesis and medicinal chemistry. During the past few decades, many new synthetic strategies toward the functionalization of quinoxalinone based scaffolds have been witnessed. Regrettably, there are only a few reports on the pharmacological activities of quinoxalinone scaffolds from a medicinal chemistry perspective. Therefore, herein we intend to outline the applications of multifunctional quinoxalinones as privileged structures possessing various biological activities, including Anticancer, neuroprotective, Antibacterial, Antiviral, antiparasitic, anti-inflammatory, antiallergic, anti-cardiovascular, anti-diabetes, antioxidation, etc. We hope that this review will facilitate the development of quinoxalinone derivatives in medicinal chemistry.

Keywords

Medicinal chemistry; Methodological application; Pharmacological activities; Quinoxalinones; Structural modification.

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