2. Academic Validation
  3. Carvone and its pharmacological activities: A systematic review

Carvone and its pharmacological activities: A systematic review

  • Phytochemistry. 2022 Apr:196:113080. doi: 10.1016/j.phytochem.2021.113080.
Lícia T S Pina 1,  Mairim R Serafini 2,  Marlange A Oliveira 3,  Laeza A Sampaio 4,  Juliana O Guimarães 3,  Adriana G Guimarães 4
Affiliations

Affiliations

  • 1 Graduate Program in Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. Electronic address: [email protected].
  • 2 Graduate Program in Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
  • 3 Graduate Program in Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
  • 4 Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
PMID: 34999510 DOI: 10.1016/j.phytochem.2021.113080
Abstract

Natural Products from Plants have gained prominence in the search for therapeutic alternatives. Monoterpenes, such as carvone, are suggested as candidates for the treatment of several diseases. Therefore, the objective of this study is to review the pharmacological activities of carvone in experimental models in vitro and in vivo. For this, the searches were carried out in May 2020 (upgraded in July 2021) in the databases of PubMed, Web of Science and Scopus and gathered studies on the pharmacological activities of carvone. Two independent reviewers performed the selection of articles using the Rayyan application, extracted the relevant data and assessed the methodological quality of the selected studies using Syrcle's risk of bias tool. Ninety-one articles were selected that described 10 pharmacological activities of carvone, such as antimicrobial, antispasmodic, anti-inflammatory, antioxidant, antinociceptive, anticonvulsant, among Others. The evaluation of the methodological quality presented an uncertain risk of bias for most studies. In LIGHT of that, carvone stands out as a viable and promising alternative in the treatment of several pathological conditions. However, carrying out studies to evaluate possible mechanisms of action and the safety of this monoterpene is recommended.

Keywords

Carvone; Monoterpene; Natural product; Pharmacological activity; Pharmacology.

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