1. Academic Validation
  2. Self-Delivery Ternary Bioregulators for Photodynamic Amplified Immunotherapy by Tumor Microenvironment Reprogramming

Self-Delivery Ternary Bioregulators for Photodynamic Amplified Immunotherapy by Tumor Microenvironment Reprogramming

  • ACS Nano. 2022 Jan 13. doi: 10.1021/acsnano.1c08978.
Lin-Ping Zhao 1 Rong-Rong Zheng 1 Ren-Jiang Kong 2 Chu-Yu Huang 1 Xiao-Na Rao 1 Ni Yang 3 A-Li Chen 1 3 Xi-Yong Yu 1 Hong Cheng 2 Shi-Ying Li 1
Affiliations

Affiliations

  • 1 Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, P.R. China.
  • 2 Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, P.R. China.
  • 3 The First Affiliated Hospital of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510080, P.R. China.
Abstract

Abnormal metabolism of Cancer cells results in complex tumor microenvironments (TME), which play a dominant role in tumor metastasis. Herein, self-delivery ternary bioregulators (designated as TerBio) are constructed for photodynamic amplified immunotherapy against colorectal Cancer by TME reprogramming. Specifically, carrier-free TerBio are prepared by the self-assembly of chlorine e6, SB505124 (SB), and lonidamine (Lon), which exhibit improved tumor accumulation, tumor penetration, and cellular uptake behaviors. Interestingly, TerBio-mediated photodynamic therapy (PDT) could not only inhibit the primary tumor growth but also induce immunogenic cell death of tumors to activate the cascade immune response. Furthermore, TerBio are capable of TME reprograming by SB-triggered transforming growth factor (TGF)-β blockage and Lon-induced lactic acid efflux inhibition. As a consequence, TerBio significantly suppresses distant and metastatic tumor growth by PDT-amplified immunotherapy. This study might advance the development of self-delivery nanomedicine against malignant tumor growth and metastasis.

Keywords

immunotherapy; photodynamic therapy; reprogramming; self-delivery; tumor microenvironment.

Figures
Products