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  3. The Design and Optimization of Monomeric Multitarget Peptides for the Treatment of Multifactorial Diseases

The Design and Optimization of Monomeric Multitarget Peptides for the Treatment of Multifactorial Diseases

  • J Med Chem. 2022 Mar 10;65(5):3685-3705. doi: 10.1021/acs.jmedchem.1c01456.
Tingkai Chen 1,  Tianyu Sun 1,  Yaoyao Bian 2,  Yuqiong Pei 3,  Feng Feng 4,  Heng Chi 4,  Yuan Li 5,  Xu Tang 3,  Shenghu Sang 3,  Chenxi Du 1,  Ying Chen 1,  Yao Chen 3,  Haopeng Sun 1
Affiliations

Affiliations

  • 1 School of Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
  • 2 College of Acupuncture and Massage, College of Regimen and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China.
  • 3 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China.
  • 4 Food and Pharmaceutical Research Institute, Jiangsu Food and Pharmaceuticals Science College, Huaian 223003, People's Republic of China.
  • 5 Department of Pharmaceutical Engineering, Jiangsu Food and Pharmaceuticals Science College, Huaian 223005, People's Republic of China.
PMID: 35188373 DOI: 10.1021/acs.jmedchem.1c01456
Abstract

Compared with single-target drugs, multitarget drugs may improve the safety and efficacy of the treatment of multifactorial diseases. However, few multitarget drugs are on the market or in clinical trials currently, and multitarget small molecules account for the majority. Compared with multitarget small molecules, multitarget Peptides have unique advantages and show good effects in a variety of diseases. This article discusses the design process of multitarget Peptides in four aspects, including target combination, peptide selection, lead generation, and lead optimization. In addition, we analyzed in detail the research cases of multitarget Peptides for several multifactorial diseases over years, aiming to reveal the trends and insights of the potential uses of multitarget Peptides.

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