2. Academic Validation
  3. Association of annexin A10 expression with poor prognosis of intrahepatic cholangiocarcinoma

Association of annexin A10 expression with poor prognosis of intrahepatic cholangiocarcinoma

  • BMC Cancer. 2022 Feb 28;22(1):219. doi: 10.1186/s12885-022-09288-8.
Yu-Yun Shao 1 2 3,  Hung-Yang Kuo 1 2 3,  Yung-Ming Jeng 4,  Yao-Ming Wu 5,  Hsiu-Po Wang 6 7,  Chiun Hsu 1 2 3,  Chih-Hung Hsu 1 2 3,  Hey-Chi Hsu 4,  Ann-Lii Cheng 1 2 3 6,  Zhong-Zhe Lin 8 9 10
Affiliations

Affiliations

  • 1 Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan.
  • 2 Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.
  • 3 Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan.
  • 4 Department of Pathology and Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan.
  • 5 Department of Surgery, National Taiwan University College of Medicine, Taipei, Taiwan.
  • 6 Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
  • 7 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • 8 Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan. [email protected].
  • 9 Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan. [email protected].
  • 10 Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. [email protected].
PMID: 35227227 DOI: 10.1186/s12885-022-09288-8
Abstract

Background: Annexin A10 expression influences the prognosis of several gastrointestinal cancers. We explored the association of annexin A10 expression with the overall survival (OS) of patients who underwent curative surgery for cholangiocarcinoma.

Methods: Patients who underwent curative surgery for cholangiocarcinoma (except gallbladder Cancer) and had pathological stage T1-3N0M0 disease were enrolled. Annexin A10 expression was examined by performing immunohistochemical staining. Patient demographics and survival outcome data were retrieved from medical records.

Results: In total, 185 patients were enrolled. The primary tumor location was intrahepatic and extrahepatic (including the perihilar region) for 89% and 11% of patients, respectively. Positive annexin A10 staining was detected for 61 (33%) patients and associated with extrahepatic or perihilar cholangiocarcinoma (p = 0.001) and lower histological grade (p < 0.001). Patients with positive annexin A10 staining exhibited significantly poorer survival relative to patients with negative staining results (median OS, 2.5 vs. 4.9 years, p = 0.025). In the multivariate analysis adjusting for age, sex, tumor location, tumor grade, hepatitis Infection, and disease stage, positive annexin A10 remained an independent predictor of poor OS (hazard ratio 1.572, p = 0.034). In the subgroup analysis, the association between annexin A10 and prognosis was restricted to intrahepatic cholangiocarcinoma. Among patients with intrahepatic cholangiocarcinoma, patients with positive annexin A10 staining exhibited significantly poorer survival compared with patients with negative annexin A10 staining (median OS, 2.3 vs. 4.9 years, p = 0.008).

Conclusion: Positive annexin A10 expression was associated with poor prognosis of intrahepatic cholangiocarcinoma.

Keywords

Annexin A10; Biliary tract cancer; Cholangiocarcinoma; Prognosis; Survival.

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