2. Academic Validation
  3. Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective

Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective

  • Front Cardiovasc Med. 2022 Feb 15:9:816369. doi: 10.3389/fcvm.2022.816369.
Li-Na Miao 1 2,  Deng Pan 1 2,  Junhe Shi 1,  Jian-Peng Du 1 3,  Peng-Fei Chen 1,  Jie Gao 1 3,  Yanqiao Yu 1 2,  Da-Zhuo Shi 1 3,  Ming Guo 1 3
Affiliations

Affiliations

  • 1 Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
  • 2 Department of Graduate School, Beijing University of Chinese Medicine, Beijing, China.
  • 3 China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
PMID: 35242825 DOI: 10.3389/fcvm.2022.816369
Abstract

Protein kinase C (PKC) is a protein kinase with important cellular functions. PKC-δ, a member of the novel PKC subfamily, has been well-documented over the years. Activation of PKC-δ plays an important regulatory role in myocardial ischemia/reperfusion (IRI) injury and myocardial fibrosis, and its activity and expression levels can regulate pathological cardiovascular diseases such as atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. This article aims to review the structure and function of PKC-δ, summarize the current research regarding its activation mechanism and its role in Cardiovascular Disease, and provide novel insight into further research on the role of PKC-δ in cardiovascular diseases.

Keywords

PKC; PKC-δ; cardiovascular disease; kinase; mechanism.

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