2. Academic Validation
  3. Procyanidins and Phlobatannins from the Twigs of Rosa multiflora and Their Neuroprotective Activity

Procyanidins and Phlobatannins from the Twigs of Rosa multiflora and Their Neuroprotective Activity

  • J Nat Prod. 2022 Apr 22;85(4):917-926. doi: 10.1021/acs.jnatprod.1c01033.
Tae Hyun Lee 1,  Seong-Min Hong 2 3,  Da Hye Yoon 2 3,  Sun Yeou Kim 2 3,  Chung Sub Kim 1 4,  Kang Ro Lee 1
Affiliations

Affiliations

  • 1 Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • 2 Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea.
  • 3 College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.
  • 4 Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
PMID: 35263118 DOI: 10.1021/acs.jnatprod.1c01033
Abstract

Three new procyanidins (1-3), two new phlobatannins (6 and 7), a new flavan-3,4-diol glycoside (9), and a new neolignan glycoside (10), along with three previously reported compounds (4, 5, and 8) were isolated from the twigs of Rosa multiflora. The chemical structures of the new compounds (1-3, 6, 7, 9, and 10) were characterized by spectroscopic data interpretation, including NMR (1H and 13C NMR, 1H-1H COSY, HSQC, HMBC, and NOESY) and HRESIMS analysis. Experimental ECD data analysis was conducted to assign the absolute configurations of the new compounds (1-3, 6, 7, 9, and 10). The absolute configuration of the sugar moieties was verified through a chiral derivatization method and LC-MS analysis. All the isolated compounds (1-10) were evaluated for their anti-neuroinflammatory activity based on inhibitory effects on nitric oxide production using a lipopolysaccharide-stimulated murine microglia BV-2 cell line and for their neurotrophic effects on nerve growth factor induction in C6 glioma.

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