2. Academic Validation
  3. Marine Natural Products as Leads against SARS-CoV-2 Infection

Marine Natural Products as Leads against SARS-CoV-2 Infection

  • J Nat Prod. 2022 Mar 25;85(3):657-665. doi: 10.1021/acs.jnatprod.2c00015.
Bhuwan Khatri Chhetri 1,  Philip R Tedbury 2,  Anne Marie Sweeney-Jones 1,  Luke Mani 3,  Katy Soapi 3,  Candela Manfredi 4,  Eric Sorscher 4,  Stefan G Sarafianos 2,  Julia Kubanek 1 5 6 7
Affiliations

Affiliations

  • 1 School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
  • 2 Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
  • 3 Institute of Applied Sciences, University of South Pacific, Suva, Fiji.
  • 4 Department of Pediatrics, Division of Pulmonary Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
  • 5 Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
  • 6 School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
  • 7 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
PMID: 35290044 DOI: 10.1021/acs.jnatprod.2c00015
Abstract

Since early 2020, disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, causing millions of infections and deaths worldwide. Despite rapid deployment of effective vaccines, it is apparent that the global community lacks multipronged interventions to combat viral Infection and disease. A major limitation is the paucity of Antiviral drug options representing diverse molecular scaffolds and mechanisms of action. Here we report the Antiviral activities of three distinct marine natural products─homofascaplysin A (1), (+)-aureol (2), and bromophycolide A (3)─evidenced by their ability to inhibit SARS-CoV-2 replication at concentrations that are nontoxic toward human airway epithelial cells. These compounds stand as promising candidates for further exploration toward the discovery of novel drug leads against SARS-CoV-2.

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