2. Academic Validation
  3. Synthesis and antiproliferative activities of novel piscidinol a derivatives as potential anticancer agents

Synthesis and antiproliferative activities of novel piscidinol a derivatives as potential anticancer agents

  • Nat Prod Res. 2022 Mar 27;1-7. doi: 10.1080/14786419.2022.2056889.
Swarna Kumari Gaja 1,  Siva Bandi 1,  Pavan Kumar Pavuluri 1,  Shainy Sambyal 2,  Vinod Kumar Jaina 3,  H M Sampath Kumar 2,  Sai Balaji Andugulapati 3 4,  Ramalingam V 1 4,  K Suresh Babu 1 4
Affiliations

Affiliations

  • 1 Centre for Natural Products & Traditional Knowledge, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.
  • 2 Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.
  • 3 Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.
  • 4 Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.
PMID: 35343322 DOI: 10.1080/14786419.2022.2056889
Abstract

Piscidinol A (1), a major compound isolated from Aphanamixis polystachya, showed modest Anticancer activity against Cancer cell lines. Subsequently, a series of analogues were synthesised by modification of the key structural functionalities of this high yield natural product and assessed for their Anticancer potential against various Cancer cell lines. Among the tested derivatives, the compounds 6e and 6i are significantly reduced the cell viability at 5.38 and 5.02 µM against DU145 prostate Cancer cells, respectively. Additionally, both the compounds arrested the cell cycle at S phase and induced the late Apoptosis in DU145 cells. Together, the results demonstrated that the compounds 6e and 6i could be a promising lead for the development of Anticancer agents against DU145 and well worth further investigation aiming to generate potential Anticancer agents.

Keywords

Aphanamixis polystachya; anticancer; apoptosis; piscidinol A; prostate cancer.

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