2. Academic Validation
  3. Advances in understanding cancer-associated neurogenesis and its implications on the neuroimmune axis in cancer

Advances in understanding cancer-associated neurogenesis and its implications on the neuroimmune axis in cancer

  • Pharmacol Ther. 2022 Nov:239:108199. doi: 10.1016/j.pharmthera.2022.108199.
Ismail Yaman 1,  Didem Ağaç Çobanoğlu 2,  Tongxin Xie 1,  Yi Ye 3,  Moran Amit 4
Affiliations

Affiliations

  • 1 Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • 2 Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • 3 Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, USA.
  • 4 Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Head and Neck Surgery, MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address: [email protected].
PMID: 35490859 DOI: 10.1016/j.pharmthera.2022.108199
Abstract

Nerves and immunologic mediators play pivotal roles in body homeostasis by interacting with each Other through diverse mechanisms. The spread of nerves in the tumor microenvironment increases tumor cell proliferation and disease progression, and this correlates with poor patient outcomes. The effects of sympathetic and parasympathetic nerves on Cancer regulation are being investigated. Recent findings demonstrate the possibility of developing therapeutic strategies that target the tumor microenvironment and its components such as immune cells, neurotransmitters, and extracellular vesicles. Therefore, examining and understanding the mechanisms and pathways associated with the sympathetic and parasympathetic nervous systems, neurotransmitters, cancer-derived mediators and their interactions with the immune system in the tumor microenvironment may lead to the development of new Cancer treatments. This review discusses the effects of nerve cells, immune cells, and Cancer cells have on each Other that regulate neurogenesis, Cancer progression, and dissemination.

Keywords

Cancer; Neuroimmune axis; Parasympathetic nervous system; Sympathetic nervous system; Tumor microenvironment.

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