2. Academic Validation
  3. The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors

The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors

  • Cell Mol Life Sci. 2022 May 9;79(6):285. doi: 10.1007/s00018-022-04321-2.
Iuliia Topchu 1,  Rajendra P Pangeni 1 2,  Igor Bychkov 1,  Sven A Miller 3,  Evgeny Izumchenko 4,  Jindan Yu 5,  Erica Golemis 3 6,  John Karanicolas 3 7,  Yanis Boumber 8 9
Affiliations

Affiliations

  • 1 Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, IL, 60611, USA.
  • 2 Department of Natural and Applied Sciences, Nexus Institute of Research and Innovation (NIRI), Sitapakha, Mahalaxmi-4, Lalitpur, Bagmati, 44700, Nepal.
  • 3 Molecular Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.
  • 4 Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL, 60637, USA.
  • 5 Department of Medicine-Hematology/Oncology and Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 303 E. Superior Street, Chicago, IL, 60611, USA.
  • 6 Department of Cancer and Cellular Biology, Lewis Katz School of Medicine at Temple University, 3500 North Broad St, Philadelphia, PA, 19140, USA.
  • 7 Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, PA, 19140, USA.
  • 8 Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, IL, 60611, USA. [email protected].
  • 9 Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, ul. 74 Karl Marks, Kazan, 420012, Russia. [email protected].
PMID: 35532818 DOI: 10.1007/s00018-022-04321-2
Abstract

NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain (NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. These structurally similar Enzymes mono- and di-methylate H3K36, which contribute to the maintenance of chromatin integrity and regulate the expression of genes that control cell division, Apoptosis, DNA repair, and epithelial-mesenchymal transition (EMT). Aberrant expression or mutation of members of the NSD family is associated with developmental defects and the occurrence of some types of Cancer. In this review, we discuss the effect of alterations in NSDs on Cancer patient's prognosis and response to treatment. We summarize the current understanding of the biological functions of NSD proteins, focusing on their activities and the role in the formation and progression in solid tumors biology, as well as how it depends on tumor etiologies. This review also discusses ongoing efforts to develop NSD inhibitors as a promising new class of Cancer therapeutic agents.

Keywords

Cancer; H3K36 methyltransferases; Histone methylation; NSD1/KMT3B; NSD2/MMSET/WHSC1; NSD3/WHSC1L1; Solid tumors.

Figures