2. Academic Validation
  3. Exosomes: Insights and therapeutic applications in cancer

Exosomes: Insights and therapeutic applications in cancer

  • Transl Oncol. 2022 Jul:21:101439. doi: 10.1016/j.tranon.2022.101439.
Anita Raj Panigrahi 1,  Lankalapalli Srinivas 2,  Jagadeesh Panda 3
Affiliations

Affiliations

  • 1 GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, 530045, India.
  • 2 GITAM Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, 530045, India. Electronic address: [email protected].
  • 3 Raghu College of Pharmacy, Dakamarri, Visakhapatnam - 531162, India.
PMID: 35551002 DOI: 10.1016/j.tranon.2022.101439
Abstract

Cancer refers to the division of abnormal cells at an uncontrollable rate that possesses the ability to infiltrate and destroy normal tissues. It frequently spreads to normal tissues throughout the body, a condition known as metastasis, which is a significant concern. It is the second leading cause of mortality globally and treatment therapy can assist in improving survival rates. Exosomes are the extracellular vesicles secreted by several cells that act as messengers between cells. When engineered, exosomes act as promising drug delivery vehicles that help achieve targeted action at the tumour site and reduce the limitations of conventional treatments such as castration, chemotherapy, radiation, etc. The present review provides an overview of exosomes, the biogenesis, sources, isolation methods and characterization. The current status and applications of chemotherapeutic agents loaded, engineered exosomes in Cancer treatment were convoluted.

Keywords

Cancer chemotherapy; Clinical trials; Drug delivery; Exosomes; Targeted drug delivery.

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