2. Academic Validation
  3. Hakuhybotric acid, a new antifungal polyketide produced by a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008

Hakuhybotric acid, a new antifungal polyketide produced by a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008

  • J Gen Appl Microbiol. 2022 Nov 22;68(4):200-206. doi: 10.2323/jgam.2022.03.002.
Yoshihiro Watanabe 1 2,  Yurika Yoshida 3,  Toshiyuki Tokiwa 1,  Mayuka Higo 1 2,  Sayaka Ban 4,  Akari Ikeda 1 2,  Yoshihiko Noguchi 1 2,  Tomoyasu Hirose 1 2,  Toshiaki Sunazuka 1 2,  Kenichi Nonaka 1 2,  Takashi Yaguchi 4,  Masato Iwatsuki 1 2
Affiliations

Affiliations

  • 1 Ōmura Satoshi Memorial Institute, Kitasato University.
  • 2 Graduate School of Infection Control Sciences, Kitasato University.
  • 3 School of Science, Kitasato University.
  • 4 Medical Mycology Research Center, Chiba University.
PMID: 35598981 DOI: 10.2323/jgam.2022.03.002
Abstract

A new Antifungal polyketide, named hakuhybotric acid (1), was isolated from a cultured broth of a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008, together with two known analogs, F2928-1 (2) and Cladobotric acid E (3). Their structures were elucidated by MS and NMR analyses. Hakuhybotric acid was a new analog of Cladobotric acid where two epoxy groups in F2928-1 were replaced with olefins. All compounds showed Antifungal activity against four different species of Aspergillus spp., the causative agents of aspergillosis. It was suggested that mycoparasitic fungi are a useful source to search Antifungal drug lead compounds.

Keywords

Hypomyces pseudocorticiicola; antifungal activity; hakuhybotric acid.

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