Cladobotric acid E
Cladobotric acid E is a potent antimicrobial agent that can be found in mycoparasitic fungi and a New Zealand Cladobotryum species. Cladobotric acid E inhibits growth of Candida auris, multiple Aspergillus species, Candida albicans, Trichophyton mentagrophytes, and Cladosporium resinae. Cladobotric acid E can be used for the research of aspergillosis, candidiasis, leukemia, bacterial infection, fungal infection.
For research use only. We do not sell to patients.
- CAS No.: 876152-18-0
- Formula: C27H36O6
- Molecular Weight:456.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Cladobotric acid E (2-64 µg/mL) potently inhibits growth of azole-sensitive and azole-resistant Candida auris strains with MICs of 2-4 µg/mL and shows moderate to weak activity against Aspergillus species with MICs of 8-64 µg/mL[1].
Cladobotric acid E (0.1-10 µg/disc; 48 h) inhibits growth of Aspergillus fumigatus IFM 61493, Aspergillus lentulus IFM 62073, Aspergillus felis IFM 62093, and Aspergillus udagawae IFM 62100 in a paper disc assay, with the largest inhibition zone (17 mm) observed against A. udagawae at 3 µg/disc[2].
Cladobotric acid E (1-256 µg/mL; 48-72 h) inhibits growth of Aspergillus fumigatus IFM 61493 with an MIC of 16 µg/mL, and Aspergillus lentulus IFM 62073, Aspergillus felis IFM 62093, and Aspergillus udagawae IFM 62100 each with an MIC of 32 µg/mL in a microdilution assay[2].
Cladobotric acid E potently inhibits the growth of murine P388 leukemia cells with an IC50 of 1.41 μM[3].
Cladobotric acid E (100 μg/disc) inhibits the growth of Bacillus subtilis with a 4 mm inhibition zone at a concentration of 100 μg/disc[3].
Cladobotric acid E (100 μg/disc) inhibits the growth of Candida albicans with a 5 mm inhibition zone at a concentration of 100 μg/disc[3].
Cladobotric acid E (100 μg/disc) inhibits the growth of Trichophyton mentagrophytes with a 2 mm inhibition zone at a concentration of 100 μg/disc[3].
Cladobotric acid E (100 μg/disc) inhibits the growth of Cladosporium resinae with a 1 mm inhibition zone at a concentration of 100 μg/disc[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 876152-18-0
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Molecular Weight 456.58
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Formula C27H36O6
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SMILES
C[C@]1([C@@]([C@@H](CC)C)(O1)[H])[C@@]2(O)[C@@H](/C=C/C=C/C=C/C(O)=O)[C@]3([C@](C=C2C)(CC(C(OC)=O)=CC3)[H])[H]
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Structure Classification
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Initial Source
Cladobotryum sp.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wang L, et al. Natural Polyketides Act as Promising Antifungal Agents. Biomolecules. 2023 Oct 24;13(11):1572. [Content Brief]
[2]. Watanabe Y, et al. Hakuhybotric acid, a new antifungal polyketide produced by a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008. J Gen Appl Microbiol. 2022 Nov 22;68(4):200-206. [Content Brief]
[3]. Mitova MI, et al. Cladobotric acids A-F: new cytotoxic polyketides from a New Zealand Cladobotryum sp. J Org Chem. 2006 Jan 20;71(2):492-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cladobotric acid E Related Classifications
HY-N19241 Related Classifications
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