Cladobotric acids A-F: new cytotoxic polyketides from a New Zealand Cladobotryum sp

  • J Org Chem. 2006 Jan 20;71(2):492-7. doi: 10.1021/jo051883l.
Maya I Mitova  1 ,  Gerhard Lang ,  John W Blunt ,  Nicholas J Cummings ,  Anthony L J Cole ,  Ward T Robinson ,  Murray H G Munro
Affiliations
  • 1. Department of Chemistry and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8020, New Zealand.
PMID: 16408955 DOI: 10.1021/jo051883l
Abstract

[reaction: see text] Cladobotric acids A-F (1-6), fungal-derived polyketides, were isolated from the fermentation broth of a New Zealand Cladobotryum species. Structures were determined by extensive spectral analysis and X-ray crystallography, and the polyketide origin of 1-6 was concluded from feeding experiments with (13)C-labeled precursors. The observed folding pattern for the polyketide chain is unusual for fungi. Cladobotric acids A-F (1-6) exhibited notable cytotoxicity against the murine P388 leukemia cell line and were also active against Bacillus subtilis and Candida albicans.

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