Hakuhybotric acid, a new antifungal polyketide produced by a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008

  • J Gen Appl Microbiol. 2022 Nov 22;68(4):200-206. doi: 10.2323/jgam.2022.03.002.
Yoshihiro Watanabe  1  2 ,  Yurika Yoshida  3 ,  Toshiyuki Tokiwa  1 ,  Mayuka Higo  1  2 ,  Sayaka Ban  4 ,  Akari Ikeda  1  2 ,  Yoshihiko Noguchi  1  2 ,  Tomoyasu Hirose  1  2 ,  Toshiaki Sunazuka  1  2 ,  Kenichi Nonaka  1  2 ,  Takashi Yaguchi  4 ,  Masato Iwatsuki  1  2
Affiliations
  • 1. Ōmura Satoshi Memorial Institute, Kitasato University.
  • 2. Graduate School of Infection Control Sciences, Kitasato University.
  • 3. School of Science, Kitasato University.
  • 4. Medical Mycology Research Center, Chiba University.
PMID: 35598981 DOI: 10.2323/jgam.2022.03.002
Abstract

A new Antifungal polyketide, named hakuhybotric acid (1), was isolated from a cultured broth of a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008, together with two known analogs, F2928-1 (2) and Cladobotric acid E (3). Their structures were elucidated by MS and NMR analyses. Hakuhybotric acid was a new analog of Cladobotric acid where two epoxy groups in F2928-1 were replaced with olefins. All compounds showed Antifungal activity against four different species of Aspergillus spp., the causative agents of aspergillosis. It was suggested that mycoparasitic fungi are a useful source to search Antifungal drug lead compounds.

Keywords
Hypomyces pseudocorticiicola; antifungal activity; hakuhybotric acid.
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