2. Academic Validation
  3. Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases

Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases

  • Mol Med. 2022 Jun 20;28(1):70. doi: 10.1186/s10020-022-00497-2.
Alejandro Quintero-Villegas 1 2,  Sergio Iván Valdés-Ferrer 3 4 5
Affiliations

Affiliations

  • 1 Department of Neurology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • 2 Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • 3 Department of Neurology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. [email protected].
  • 4 Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. [email protected].
  • 5 Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, NY, USA. [email protected].
PMID: 35725396 DOI: 10.1186/s10020-022-00497-2
Abstract

5-HT7 receptors (5-HT7R) are the most recently identified among the family of serotonin receptors. Their role in health and disease, particularly as mediators of, and druggable targets for, neurodegenerative diseases, is incompletely understood. Unlike Other serotonin receptors, for which abundant preclinical and clinical data evaluating their effect on neurodegenerative conditions exist, the available information on the role of the 5-HT7R receptor is limited. In this review, we describe the signaling pathways and cellular mechanisms implicated in the activation of the 5-HT7R; also, we analyze different mechanisms of neurodegeneration and the potential therapeutic implications of pharmacological interventions for 5-HT7R signaling.

Keywords

5-HT7; Alzheimer disease; Dementia; Neurodegeneration; Neuroprotection; Parkinson disease.

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