2. Academic Validation
  3. Oxalierpenes A and B, Unusual Indole-Diterpenoid Derivatives with Antiviral Activity from a Marine-Derived Strain of the Fungus Penicillium oxalicum

Oxalierpenes A and B, Unusual Indole-Diterpenoid Derivatives with Antiviral Activity from a Marine-Derived Strain of the Fungus Penicillium oxalicum

  • J Nat Prod. 2022 Jul 22;85(7):1880-1885. doi: 10.1021/acs.jnatprod.2c00322.
Ya-Hui Zhang 1,  Lei Li 1,  Ya-Qi Li 1,  Jia-Hua Luo 1,  Wan Li 1,  Long-Fei Li 1,  Cai-Juan Zheng 2,  Fei Cao 1
Affiliations

Affiliations

  • 1 College of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Hebei University, Baoding 071002, People's Republic of China.
  • 2 Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, People's Republic of China.
PMID: 35729787 DOI: 10.1021/acs.jnatprod.2c00322
Abstract

Oxalierpenes A and B (1 and 2), two unusual indole-diterpenoid derivatives, were obtained from the marine-derived fungus Penicillium oxalicum. The absolute configurations of 1 and 2 were elucidated by calculated TDDFT ECD and DP4plus methods. Oxalierpene A (1) represents the first indole-diterpenoid derivative with a five-membered ring of 4-hydroxy-5,5-dimethyldihydrofuran-3-one as a side chain. Oxalierpene B (2) has a unique 6/5/6/5/5/6/6/5/5 ring system. Compounds 1 and 2 showed Antiviral activity against the H1N1 virus and respiratory syncytial virus (RSV), with IC50 values ranging from 2.8 to 9.4 μM.

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