2. Academic Validation
  3. Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

  • Physiology (Bethesda). 2022 Nov 1;37(6):311-322. doi: 10.1152/physiol.00007.2022.
Timothy D O'Connell 1,  Katherine A Murphy 1,  Naixin Zhang 1,  Sara J Puccini 1,  Chastity L Healy 1,  Brian A Harsch 2,  Michael J Zhang 1,  Gregory C Shearer 2
Affiliations

Affiliations

  • 1 Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.
  • 2 Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania.
PMID: 35944007 DOI: 10.1152/physiol.00007.2022
Abstract

A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free Fatty Acid Receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyunsaturated fatty acids (ω3-PUFAs), that attenuates Metabolic Disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, Free Fatty Acid Receptor 4, and attenuation of cardiometabolic disease.

Keywords

18-hydroxyeicosapentaenoic acid (18-HEPE); cardiometabolic disease; free fatty acid receptor 4 (Ffar4); heart; specialized proresolving mediators (SPM); ω3-polyunsaturated fatty acids (ω3-PUFAs).

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