2. Academic Validation
  3. Role of Fe, Transferrin and Transferrin Receptor in Anti-Tumor Effect of Vitamin C

Role of Fe, Transferrin and Transferrin Receptor in Anti-Tumor Effect of Vitamin C

  • Cancers (Basel). 2022 Sep 17;14(18):4507. doi: 10.3390/cancers14184507.
Jia Qiu 1,  Renbo Wu 1,  Yali Long 1,  Lei Peng 1,  Tianhong Yang 1,  Bing Zhang 1,  Xinchong Shi 1,  Jianbo Liu 1,  Xiangsong Zhang 1
Affiliations

Affiliation

  • 1 Department of Nuclear Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Zhongshan Er Road, Guangzhou 510030, China.
PMID: 36139668 DOI: 10.3390/cancers14184507
Abstract

High-dose vitamin C (VC) exhibits anti-tumor effects, and the cytotoxicity of VC is correlated with oxidative stress. However, iron, as a redox metal, plays an important effect in redox cycling and free radical formation in cells. This study addresses the role of iron ion in the cytotoxicity of VC. We found that iron supplementation increases the anti-tumor effect of VC, which was influenced by the cellular iron uptake pathway-transferrin (TF)/Transferrin Receptor (TFR) system. The TFR expression of tumors can be assessed by 68Ga-citrate PET imaging, and it would be helpful to screen out the tumor type which is more sensitive to VC combined with an iron supplementation treatment.

Keywords

PET-CT; iron content; transferrin/transferrin receptor; vitamin C.

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