2. Academic Validation
  3. GPX4-independent ferroptosis-a new strategy in disease's therapy

GPX4-independent ferroptosis-a new strategy in disease's therapy

  • Cell Death Discov. 2022 Oct 30;8(1):434. doi: 10.1038/s41420-022-01212-0.
Tianyu Ma 1,  Jingtong Du 2,  Yufeng Zhang 1,  Yuyao Wang 1,  Bingxuan Wang 1,  Tianhong Zhang 3
Affiliations

Affiliations

  • 1 Department of Otorhinolaryngology Head and Neck surgery, The First Hospital affiliated to Harbin Medical University, Harbin, Heilongjiang, China.
  • 2 Department of Reproductive Endocrinology, The Second Hospital affiliated to Harbin Medical University, Harbin, China.
  • 3 Department of Otorhinolaryngology Head and Neck surgery, The First Hospital affiliated to Harbin Medical University, Harbin, Heilongjiang, China. [email protected].
PMID: 36309489 DOI: 10.1038/s41420-022-01212-0
Abstract

Ferroptosis is a form of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation, and earlier studies identified Glutathione Peroxidase 4 (GPX4) as an essential regulator of this process. Ferroptosis plays an essential role in tumors, degenerative diseases, and ischemia-reperfusion injury. However, researchers have found that inhibition of GPX4 does not entirely suppress Ferroptosis in certain diseases, or cells express resistance to Ferroptosis agonists that inhibit GPX4. As research progresses, it has been discovered that there are multiple regulatory pathways for Ferroptosis that are independent of GPX4. The study of GPX4-independent Ferroptosis pathways can better target Ferroptosis to prevent and treat various diseases. Here, the currently inhibited pulmonary GPX4-dependent Ferroptosis pathways will be reviewed.

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