2. Academic Validation
  3. A comprehensive overview of Artemisinin and its derivatives as anticancer agents

A comprehensive overview of Artemisinin and its derivatives as anticancer agents

  • Eur J Med Chem. 2023 Feb 5:247:115000. doi: 10.1016/j.ejmech.2022.115000.
Zi-Wei Zeng 1,  Di Chen 1,  Lei Chen 1,  Bin He 2,  Yan Li 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, School of Basic Medical Science, Guizhou Medical University, Guiyang, 550004, China.
  • 2 State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, School of Basic Medical Science, Guizhou Medical University, Guiyang, 550004, China. Electronic address: [email protected].
  • 3 State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, School of Basic Medical Science, Guizhou Medical University, Guiyang, 550004, China. Electronic address: [email protected].
PMID: 36538859 DOI: 10.1016/j.ejmech.2022.115000
Abstract

Artemisinin is the crucial ingredient of artemisia annua, a traditional Chinese medicine used for the therapy of malaria in China for hundreds of years. In recent years, the Anticancer properties of artemisinin and its derivatives have also been reported. This review has summarized the research and development of artemisinin and its derivatives as Anticancer agents, which included both natural and synthetic monomers as well as their dimers. In addition, it highlights the antitumor effects of artemisinin and its derivatives after site-modification or after transformation to a nano-delivery system. Moreover, we have further explored their potential mechanisms of action and also discussed the clinical trials of ARTs used to treat Cancer, which will facilitate in further development of novel Anticancer drugs based on the scaffold of artemisinin.

Keywords

Anticancer; Antimalarial; Artemisinin; Derivatives; Mechanism.

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