2. Academic Validation
  3. Effects of ifenprodil glucuronide derivative on platelet aggregation and vasocontraction

Effects of ifenprodil glucuronide derivative on platelet aggregation and vasocontraction

  • Jpn J Pharmacol. 1987 Jul;44(3):355-7. doi: 10.1254/jjp.44.355.
K Saitoh 1,  T Manabe,  H Honda,  O Irino
Affiliations

Affiliation

  • 1 Research Laboratory, Grelan Pharmaceutical, Co., Ltd., Tokyo, Japan.
PMID: 3656787 DOI: 10.1254/jjp.44.355
Abstract

It has been supposed that ifenprodil glucuronide derivative, detectable in large amount in rabbit plasma, is related to the pharmacological actions by ifenprodil tartrate. However, a synthesized ifenprodil glucuronide derivative was found to have no effect on platelet aggregation and vasocontraction in vitro. These results indicate that ifenprodil itself rather than its glucuronide derivative manifested the pharmacological actions.

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