2. Academic Validation
  3. Lignans from the genus Piper L. and their pharmacological activities: An updated review

Lignans from the genus Piper L. and their pharmacological activities: An updated review

  • Fitoterapia. 2023 Mar;165:105403. doi: 10.1016/j.fitote.2022.105403.
Dongsheng Fan 1,  Chanyuan Zhou 2,  Chengyu Chen 3,  Xiaoqian Li 1,  Jiangxiong Ma 4,  Yujie Hu 1,  Guangsong Li 1,  Jinghua Ruan 1,  Anguo Wu 5,  Ling Li 6,  Xiaojian Gong 7
Affiliations

Affiliations

  • 1 Department of Pharmacy, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550001, China.
  • 2 College of Chemistry and Materials Engineering, Guiyang University, Guiyang, Guizhou 550005, China.
  • 3 Jiaheng (Hengqin, Zhuhai) Pharmaceutical Technology Co., Ltd., Zhuhai, Guangdong 519000, China.
  • 4 Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang,Guizhou 550001, China.
  • 5 Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Key Laboratory of Medical Electrophysiology of Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: [email protected].
  • 6 Department of Pharmacy, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550001, China. Electronic address: [email protected].
  • 7 Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang,Guizhou 550001, China. Electronic address: [email protected].
PMID: 36577457 DOI: 10.1016/j.fitote.2022.105403
Abstract

The genus Piper, a member of the Piperaceae family, comprises >2000 species, of which many are well known to possess considerable economic and medicinal values. Lignans are essential ingredients and are rich in Piper Plants. Although many phytochemical studies have reported many Lignans identified from Piper Plants, comprehensive research has not reviewed these compounds. Hence, the present review reports on natural Lignans from the genus Piper and their pharmacological activities. At least 275 Lignans have been discovered from the Piper genus until October 2022, including traditional Lignans, neolignans, oxyneolignans, norlignans, secolignans, and polyneolignans, especially some neolignans and norlignans with novel and complex scaffolds. In addition, these Lignans have been reported to show various pharmacological activities, such as antimicrobial, anti-inflammatory, neuroprotective, antioxidative, anti-platelet aggregation, cytotoxic, Anti-parasitic, CYP3A4 inhibitory activities, and so on. The current work presents an up-to-date critical review and a systematic summary of publications on Lignans from the genus Piper to lay the groundwork and show better insights for further investigations.

Keywords

Lignans; Neolignans; Oxyneolignans; Pharmacological activities; Piper.

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