2. Academic Validation
  3. Role of ACSL5 in fatty acid metabolism

Role of ACSL5 in fatty acid metabolism

  • Heliyon. 2023 Jan 31;9(2):e13316. doi: 10.1016/j.heliyon.2023.e13316.
Qin Luo 1 2,  Avash Das 3,  Federico Oldoni 3,  Panyun Wu 1 2 3,  Jiangang Wang 4,  Fei Luo 1 2,  Zhenfei Fang 1 2
Affiliations

Affiliations

  • 1 Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
  • 2 Research Institute of Blood Lipid and Atherosclerosis, The Second Xiangya Hospital, Central South University, Hunan, 410011, China.
  • 3 Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • 4 Department of Health Management, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
PMID: 36816310 DOI: 10.1016/j.heliyon.2023.e13316
Abstract

Free fatty acids (FFAs) are essential energy sources for most body tissues. A fatty acid must be converted to fatty acyl-CoA to oxidize or be incorporated into new lipids. Acyl-CoA synthetase long-chain family member 5 (ACSL5) is localized in the endoplasmic reticulum and mitochondrial outer membrane, where it catalyzes the formation of fatty acyl-CoAs from long-chain fatty acids (C16-C20). Fatty acyl-CoAs are then used in lipid synthesis or β-oxidation mediated pathways. ACSL5 plays a pleiotropic role in lipid metabolism depending on substrate preferences, subcellular localization and tissue specificity. Here, we review the role of ACSL5 in fatty acid metabolism in multiple metabolic tissues, including the liver, small intestine, adipose tissue, and skeletal muscle. Given the increasing number of studies suggesting the role of ACSL5 in glucose and lipid metabolism, we also summarized the effects of ACSL5 on circulating lipids and Insulin resistance.

Keywords

ACSL5; Energy homeostasis; Fatty acid; Insulin resistance; Lipid metabolism.

Figures