2. Academic Validation
  3. Active constituents with α-glucosidase inhibitory activities from Sabia parviflora

Active constituents with α-glucosidase inhibitory activities from Sabia parviflora

  • Fitoterapia. 2023 Jun:167:105516. doi: 10.1016/j.fitote.2023.105516.
Qi-Hui Hong 1,  Jiang Li 2,  Lu-Lu Deng 2,  Xiao-Jiang Hao 3,  Shu-Zhen Mu 4
Affiliations

Affiliations

  • 1 School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products Research Center of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
  • 2 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products Research Center of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
  • 3 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products Research Center of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China; Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming 650201, China.
  • 4 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products Research Center of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China. Electronic address: [email protected].
PMID: 37100353 DOI: 10.1016/j.fitote.2023.105516
Abstract

To identify the active constituents with α-glucosidase inhibitory activities in Sabia parviflora, three new compounds, namely, sabiaparviflora A-C (1, 2 and 8), and seven known compounds were isolated from the plant by repeated column chromatography. The structures of the new compounds were identified by extensive application of spectroscopic methods, including 1H NMR, 13C NMR, IR and HR-ESI-MS. All compounds, except for compounds 3-5, 9 and 10 were isolated for the first time from S. parviflora. Their α-glucosidase inhibitory activities were evaluated for the first time by the PNPG method. Three compounds (1, 7 and 10) exhibited marked activities, with IC50 values ranging from 104 to 324 μM, and their structure-activity relationship is preliminarily discussed herein.

Keywords

Aporphine alkaloids; Pentacyclic triterpenoids; Sabia parviflora; α-Glucosidase inhibitory activities.

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