2. Academic Validation
  3. Antimicrobial metabolites produced by endophytic fungi associated with the leaves of Vochysia divergens

Antimicrobial metabolites produced by endophytic fungi associated with the leaves of Vochysia divergens

  • Nat Prod Res. 2023 May 8:1-8. doi: 10.1080/14786419.2023.2208723.
Jéssica A de M Souza 1,  Juliana R Gubiani 2,  Kátia A de Siqueira 3,  Maria J de Camargo 4,  Walmir S Garcez 5,  Paulo T de Sousa Jr 1,  Marcos A Soares 3,  Ângela R Araújo 6,  Emanuel V Dos S Nunes 6,  Lucas C C Vieira 1,  Olívia M Sampaio 1,  Letícia S Goulart 7,  Carolina R Biasetto 6,  Orivaldo T de Menezes Jr 8,  Camila M de Oliveira 9,  Cláudio R Nogueira 10,  Luciano da S Pinto 11,  Helder L Teles 9
Affiliations

Affiliations

  • 1 Department of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil.
  • 2 Institute of Chemistry of São Carlos, São Paulo University, São Carlos, Brazil.
  • 3 Institute of Biosciences, Federal University of Mato Grosso, Cuiabá, Brazil.
  • 4 Military College of Campo Grande, Campo Grande, Brazil.
  • 5 Institute of Chemistry, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
  • 6 Institute of Chemistry, Department of Biochemistry and Organic Chemistry, NuBBE, São Paulo State University, Araraquara, Brazil.
  • 7 Faculty of Health Sciences, Federal University of Rondonópolis, Rondonópolis, Brazil.
  • 8 Institute of Exact Sciences and Technology, Federal University of Amazonas, Itacoatiara, Brazil.
  • 9 Institute of Exact and Natural Sciences, Federal University of Rondonópolis, Rondonópolis, Brazil.
  • 10 Faculty of Exact Sciences and Technology, Federal University of Grande Dourados, Dourados, Brazil.
  • 11 Department of Chemistry, Federal University of São Carlos, São Carlos, Brazil.
PMID: 37154616 DOI: 10.1080/14786419.2023.2208723
Abstract

Investigation of the endophytic fungi Nigrospora sphaerica, Nigrospora oryzae, and Pseudofusicoccum stromaticum MeOH fractions isolated from the leaves of Vochysia divergens, a medicinal species from the Brazilian Pantanal, led to the identification of five compounds, namely a new compound (1E,8Z)-10,11-dihydroxy-5,5,8-trimethyl-4-oxocycloundeca-1,8-diene-1-carbaldehyde (1) and four known compounds: 5-methylmellein (2), sclerone (3), daldinone A (4), and lasiodiplodin (5). All compounds were identified using spectroscopic methods, and 1 was corroborated with mass spectrometry, while the known compounds were compared with data in the literature. The relative configuration of compound 1 was determined based on theoretical conformational studies as well as the J experimental values between the hydroxymethyne hydrogens. The antimicrobial activity of the compounds was evaluated. Promising results were obtained for compounds 2, 4, and 5 since they inhibited the bacterium Pseudomonas aeruginosa, an opportunistic pathogen, suggesting the potential of these Microorganisms as a source of new Antibacterial agents.

Keywords

Endophytic fungi; Vochysia divergens; antibacterial activity.

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