2. Academic Validation
  3. A Stepwise Targeting and Antibacterial Strategy by Leukocyte Membrane-Based Conjugated Oligomer Nanoparticles

A Stepwise Targeting and Antibacterial Strategy by Leukocyte Membrane-Based Conjugated Oligomer Nanoparticles

  • ACS Appl Bio Mater. 2023 Jun 8. doi: 10.1021/acsabm.3c00277.
Xiao Wei 1,  Xiaoning Liu 2,  Xinyue Liu 1,  Junjie Qi 1,  Chengfen Xing 2
Affiliations

Affiliations

  • 1 National-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300131, P.R. China.
  • 2 Key Laboratory of Hebei Province for Molecular Biophysics, Institute of Biophysics, Hebei University of Technology, Tianjin 300401, P.R. China.
PMID: 37289442 DOI: 10.1021/acsabm.3c00277
Abstract

Bacterial infection poses an enormous threat to human life and health. The inability of drugs to be effectively delivered to the site of Infection and the development of Bacterial resistance make the treatment process more difficult. Herein, a stepwise targeted biomimetic nanoparticle (NPs@M-P) with inflammatory tendency and Gram-negative Bacterial targeting was designed, which can achieve efficient Antibacterial activity under near-infrared triggering. Leukocyte membranes and targeted molecules (PMB) are used to deliver NPs to the surface of Gram-negative bacteria. The heat and ROS released by NPs@M-P can efficiently kill Gram-negative bacteria under low-power near-infrared LIGHT. Thus, this multimodal combination therapy strategy has broad promise in fighting Bacterial infection and avoiding drug resistance.

Keywords

Gram-negative bacteria; antibacterial; biomimetic nanoparticles; near-infrared light; stepwise targeting.

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