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  3. Polymyxin B1

Polymyxin B1 

Cat. No.: HY-A0248A Purity: >96.0%
Handling Instructions

Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.

For research use only. We do not sell to patients.

Polymyxin B1 Chemical Structure

Polymyxin B1 Chemical Structure

CAS No. : 4135-11-9

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment[1][2].

In Vitro

Polymyxin B1 has antimicrobial activity that againsts Pseudomonas aeruginosa ATCC 27853, Acinetobacter baumannii ATCC BAA 747, Klebsiella pneumoniae ATCC 13883, P. aeruginosa 9019, A. baumannii 1261 and K. pneumoniae VM9 isolates with MIC values of 4 μg/mL, 2 μg/mL, 2 μg/mL, 4 μg/mL, 4 μg/mL and 2 μg/mL, respectively[3].
Polymyxin B1 strongly inhibits protein synthesis in yeast, and in E. coli and S. aureus[4].

In Vivo

The pharmacokinetics of Polymyxin B1 is investigated in a rat model following intravenous administration (0.8 mg/kg). The area under the concentration-time curve for Polymyxins B1 is greater than those of colistins A and B. Colistin A colistin B. The clearance value of Polymyxins B1 is 2.39 mL/min/kg, the plasma protein binding is 82.3%, the elimination half-life is 79.5 min and the AUC0-∞ is 365 mg•min/L[5].

Molecular Weight

1203.48

Formula

C₅₆H₉₈N₁₆O₁₃

CAS No.

4135-11-9

SMILES

O=C(N[[email protected]](C(N[[email protected]@](C(N[[email protected]](C(N[[email protected]@]1([H])[[email protected]](O)C)=O)CCN)=O)([H])CCN)=O)CC(C)C)[[email protected]](NC([[email protected]@H](NC([[email protected]@](CCNC1=O)([H])NC([[email protected]](CCN)NC([[email protected]]([[email protected]](O)C)NC([[email protected]](CCN)NC(CCCC[[email protected]@H](C)CC)=O)=O)=O)=O)=O)CCN)=O)CC2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References

Purity: >96.0%

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Keywords:

Polymyxin B1Polymyxin B 1Polymyxin B-1BacterialPolypeptideantibioticmultidrug-resistantGram-negativeinfectionsantimicrobialmembraneslipopeptideInhibitorinhibitorinhibit

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