2. Academic Validation
  3. Multi-omics reveals aspirin eugenol ester alleviates neurological disease

Multi-omics reveals aspirin eugenol ester alleviates neurological disease

  • Biomed Pharmacother. 2023 Aug 10;166:115311. doi: 10.1016/j.biopha.2023.115311.
Qi Tao 1,  Zhen-Dong Zhang 1,  Xiao-Rong Lu 1,  Zhe Qin 1,  Xi-Wang Liu 1,  Shi-Hong Li 1,  Li-Xia Bai 1,  Bo-Wen Ge 1,  Jian-Yong Li 2,  Ya-Jun Yang 3
Affiliations

Affiliations

  • 1 Key Lab of New Animal Drug Project of Gansu Province, Key Lab of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China.
  • 2 Key Lab of New Animal Drug Project of Gansu Province, Key Lab of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China. Electronic address: [email protected].
  • 3 Key Lab of New Animal Drug Project of Gansu Province, Key Lab of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China. Electronic address: [email protected].
PMID: 37572635 DOI: 10.1016/j.biopha.2023.115311
Abstract

Background: Exosomes play an essential role in maintaining normal brain function due to their ability to cross the blood-brain barrier. Aspirin eugenol ester (AEE) is a new medicinal compound synthesized by the esterification of aspirin with eugenol using the prodrug principle. Aspirin has been reported to have neuroprotective effects and may be effective against neurodegenerative diseases.

Purpose: This study wanted to investigate how AEE affected neurological diseases in vivo and in vitro.

Experimental approach: A multi-omics approach was used to explore the effects of AEE on the nervous system. Gene and protein expression changes of BDNF and NEFM in SY5Y cells after AEE treatment were detected using RT-qPCR and Western Blot.

Key results: The multi-omics results showed that AEE could regulate neuronal synapses, neuronal axons, neuronal migration, and neuropeptide signaling by affecting transport, inflammatory response, and regulating Apoptosis. Exosomes secreted by AEE-treated Caco-2 cells could promote the growth of neurofilaments in SY5Y cells and increased the expression of BDNF and NEFM proteins in SY5Y cells. miRNAs in the exosomes of AEE-treated Caco-2 cells may play an important role in the activation of SY5Y neuronal cells.

Conclusions: In conclusion, AEE could play positive effects on neurological-related diseases.

Keywords

Aspirin eugenol ester (AEE); Exosomes; Gut microbiota; MiRNAs; Transcriptomics.

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