2. Academic Validation
  3. Natural products as potential lead compounds to develop new antiviral drugs over the past decade

Natural products as potential lead compounds to develop new antiviral drugs over the past decade

  • Eur J Med Chem. 2023 Nov 15:260:115726. doi: 10.1016/j.ejmech.2023.115726.
Jing-Han Zhao 1,  Yue-Wei Wang 1,  Jin Yang 1,  Zhen-Jiang Tong 1,  Jia-Zhen Wu 1,  Yi-Bo Wang 1,  Qing-Xin Wang 1,  Qing-Qing Li 1,  Yan-Cheng Yu 1,  Xue-Jiao Leng 1,  Liang Chang 1,  Xin Xue 1,  Shan-Liang Sun 1,  He-Min Li 1,  Ning Ding 2,  Jin-Ao Duan 3,  Nian-Guang Li 4,  Zhi-Hao Shi 5
Affiliations

Affiliations

  • 1 National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023, China.
  • 2 National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023, China. Electronic address: [email protected].
  • 3 National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023, China. Electronic address: [email protected].
  • 4 National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023, China. Electronic address: [email protected].
  • 5 Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China. Electronic address: [email protected].
PMID: 37597436 DOI: 10.1016/j.ejmech.2023.115726
Abstract

Virus Infection has been one of the main causes of human death since the ancient times. Even though more and more Antiviral drugs have been approved in clinic, long-term use can easily lead to the emergence of drug resistance and side effects. Fortunately, there are many kinds of metabolites which were produced by Plants, marine organisms and Microorganisms in nature with rich structural skeletons, and they are natural treasure house for people to find Antiviral active substances. Aiming at many types of viruses that had caused serious harm to human health in recent years, this review summarizes the natural products with Antiviral activity that had been reported for the first time in the past ten years, we also sort out the source, chemical structure and safety indicators in order to provide potential lead compounds for the research and development of new Antiviral drugs.

Keywords

Chemical structure; Drug resistance; Natural products; Source; Virus.

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