2. Academic Validation
  3. Antitumor agents, 79. Cytotoxic antileukemic alkaloids from Brucea antidysenterica

Antitumor agents, 79. Cytotoxic antileukemic alkaloids from Brucea antidysenterica

  • J Nat Prod. 1986 May-Jun;49(3):428-34. doi: 10.1021/np50045a007.
N Fukamiya,  M Okano,  T Aratani,  K Negoro,  A T McPhail,  M Ju-ichi,  K H Lee
PMID: 3760882 DOI: 10.1021/np50045a007
Abstract

Two cytotoxic antileukemic Alkaloids, the new 1,11-dimethoxycanthin-6-one (3) and the known 11-hydroxycanthin-6-one (1), as well as the known canthin-6-one (2) were isolated from the stem of Brucea antidysenterica. The structures of 1-3 were determined from their spectral data and X-ray analysis of the o-bromobenzoate of 1.

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