2. Academic Validation
  3. IL-32 as a potential biomarker and therapeutic target in skin inflammation

IL-32 as a potential biomarker and therapeutic target in skin inflammation

  • Front Immunol. 2023 Sep 1:14:1264236. doi: 10.3389/fimmu.2023.1264236.
Alexandra Wallimann 1,  Mirjam Schenk 1 2
Affiliations

Affiliations

  • 1 Christine Kühne - Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
  • 2 Institute of Tissue Medicine and Pathology, Experimental Pathology, University of Bern, Bern, Switzerland.
PMID: 37727785 DOI: 10.3389/fimmu.2023.1264236
Abstract

IL-32 is a recently described cytokine that performs a variety of functions under inflammatory conditions. Serum IL-32 has been shown to be elevated in several diseases, including type 2 diabetes, Cancer, systemic lupus erythematosus, HIV Infection, and atopic diseases including atopic dermatitis. There are nine different isoforms of IL-32, with IL-32γ being the most biologically active one. The following review summarizes the different roles of the various IL-32 isoforms in the context of skin inflammation, with a focus on atopic dermatitis.

Keywords

CTCL; IL-32; atopic dermatitis; infection; melanoma; skin inflammation.

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